Comparative early embryology
Mammalian early embryos share multiple features, and early developmental processes are widely regarded as highly conserved. However, major cell specification events are species-specific. In this branch of the lab, we aim to uncover what are the shared and unique molecular and cellular processes that govern cell fate decisions across species.
Interorganismal fetal-maternal interface
The intimate interaction between the developing embryo and the uterine microenvironment is central for a successful pregnancy. This dynamic crosstalk does not only shape the embryo proper, but it is essential for the health of the mother. Here, we study how this elegant interface between two organisms is established and regulated.
Evolutionary morphogenesis
The placenta is an essential organ for the success of mammalian reproduction. Even though the internal organs are structurally similar in the early embryonic stages across mammals, the placenta evolved strikingly different architectures. By taking an evolutionary approach, we aim to understand the mechanisms underlying how placenta became different from a morphological point of view, while retaining a similar function across species.
